Abstract Contact sites, areas where two organelles are held in close proximity through the action of molecular tethers, enable non-vesicular communication between compartments. Mitochondria have been center stage in the contact site field since the discovery of the first contact between mitochondria and the endoplasmic reticulum (ER) over 60 years ago. However, only now, in the last decade, has there been a burst of discoveries regarding contact site biology in general and mitochondrial contacts specifically. The number and types of characterized contacts increased dramatically, new molecular mechanisms enabling contact formation were discovered, additional unexpected functions for contacts were shown, and their roles in cellular and organismal physiology were emphasized. Here, we focus on mitochondria as we highlight the most recent developments, future goals and unresolved questions in the field.

中文翻译：

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线粒体接触位点研究的新视野

摘要 接触部位，即两个细胞器通过分子系链的作用紧密相连的区域，使隔室之间能够进行非囊泡通信。自 60 多年前发现线粒体与内质网 (ER) 之间的第一次接触以来，线粒体一直是接触部位领域的中心舞台。然而，直到现在，在过去十年中，才出现了大量关于一般接触位点生物学和特别是线粒体接触的发现。表征接触的数量和类型急剧增加，发现了能够形成接触的新分子机制，显示了接触的其他意想不到的功能，并强调了它们在细胞和生物体生理学中的作用。在这里，我们重点关注线粒体，因为我们强调了最新的发展，