Aim: Cardiac autonomic neuropathy (CAN) is a common and important chronic complication in diabetic patients. Heart failure resulting from cardiomyopathy is also a lethal complication in diabetic patients. However, data showing the exact association between CAN and heart failure in diabetic patients are relatively scarce. Therefore, our study aimed to determine the association between the parameters assessing CAN and heart function in diabetic patients.

Method: The medical records of type 2 diabetic patients who underwent an autonomic function test with heart rate variability (HRV) and echocardiography were reviewed from January 2018 to December 2018. A total of 100 type 2 diabetic patients were included, and the association between the parameters assessing CAN and heart function was analysed.

Results: Among the 100 analysed patients, 65 were diagnosed with CAN and 26 showed diastolic dysfunction. Moreover, 19 (73.1%) diabetic patients with diastolic dysfunction were complicated with CAN. The occurrence of diastolic dysfunction was higher in diabetic patients with CAN than in diabetic patients without CAN (29.2% vs 20.0%, p < 0.05), and the occurrence of CAN was higher in diabetic patients with diastolic dysfunction than in patients without diastolic dysfunction (73.1% vs 62.2%, p < 0.05). However, there were no significant associations between HRV parameters and heart function.

Conclusion: We demonstrated that diastolic dysfunction is more common in diabetic patients complicated with CAN than in diabetic patients without CAN, although several diabetic patients without diastolic dysfunction are also diagnosed with CAN. Moreover, further studies about the long-term serial monitoring of heart function according to the progression of CAN are required to confirm the exact association between CAN and heart function.

目的：心脏自主神经病变（CAN）是糖尿病患者常见且重要的慢性并发症。由心肌病引起的心力衰竭也是糖尿病患者的致命并发症。然而，显示 CAN 与糖尿病患者心力衰竭之间确切关联的数据相对较少。因此，我们的研究旨在确定评估 CAN 的参数与糖尿病患者心脏功能之间的关联。

方法：回顾性分析2018年1月至2018年12月接受自主神经功能检查、心率变异性（HRV）和超声心动图检查的2型糖尿病患者的病历，共纳入100例2型糖尿病患者，并分析两者之间的相关性。分析了评估 CAN 和心脏功能的参数。

结果：在分析的 100 名患者中，65 名被诊断为 CAN，26 名显示舒张功能障碍。此外，19 名（73.1%）舒张功能障碍的糖尿病患者并发 CAN。合并CAN的糖尿病患者舒张功能障碍的发生率高于未合并CAN的糖尿病患者（29.2% vs 20.0%，p < 0.05），且有舒张功能障碍的糖尿病患者发生CAN的发生率高于未合并舒张功能障碍的糖尿病患者（ 73.1% 与 62.2%，p < 0.05）。然而，HRV 参数与心脏功能之间没有显着关联。

结论：我们证明，合并 CAN 的糖尿病患者的舒张功能障碍比没有 CAN 的糖尿病患者更常见，尽管一些没有舒张功能障碍的糖尿病患者也被诊断出患有 CAN。此外，还需要进一步研究根据 CAN 的进展对心脏功能进行长期连续监测，以确认 CAN 与心脏功能之间的确切关联。