Purpose

There are conflicting results of studies investigating the association between the tumor necrosis factor (TNF) and angiotensin-converting enzyme (ACE) gene polymorphisms and Behcet’s disease (BD). The aim of this meta-analysis is to assess the association between these gene polymorphisms and ocular involvement in BD.

Methods

We identified relevant studies and reviewed the full-text manuscripts of the studies in order to select those for inclusion. Heterogeneity of studies was evaluated using Cochran Q-test and I-square index. To modify the heterogeneity in the variables we used random effects model. Meta-analysis was performed using STATA.

Results

We analyzed TNF-1031, −308 and ACE DD/II genotype difference between BD patients with and without uveitis. Among these polymorphic genetic loci TNF-308 AA genotype has a statistically significant protective effect against BD uveitis (OR = 0.45 vs 1.23, p = .017). Such a statistically significant effect was not seen for other studied genotypes.

Conclusion

This meta-analysis revealed a significant protective effect of TNF-308 AA genotype against ocular involvement in Behcet’s disease.

中文翻译：

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肿瘤坏死因子（TNF）-308，-1031和血管紧张素转换酶（ACE）DD / II多态性在有或无葡萄膜炎的贝塞特病中的作用：一项荟萃分析。

目的

研究肿瘤坏死因子（TNF）与血管紧张素转换酶（ACE）基因多态性与白塞病（BD）之间的关联性的研究存在矛盾的结果。这项荟萃分析的目的是评估这些基因多态性与BD眼部受累之间的关联。

方法

我们确定了相关研究，并审查了研究的全文手稿，以便选择要纳入的研究。使用Cochran Q检验和I平方指数评估研究的异质性。为了修改变量的异质性，我们使用了随机效应模型。使用STATA进行荟萃分析。

结果

我们分析了有和没有葡萄膜炎的BD患者之间的TNF-1031，−308和ACE DD / II基因型差异。在这些多态性遗传基因座中，TNF-308 AA基因型对BD葡萄膜炎具有统计学上的显着保护作用（OR = 0.45对1.23，p = .017）。对于其他已研究的基因型，未见这种统计学上显着的影响。

结论

这项荟萃分析显示，TNF-308 AA基因型对白塞病患者的眼部感染具有明显的保护作用。