As the proportion of the elderly population increases, more and more people suffer from aging-related diseases. Even if aging is inevitable, prolonging the time of healthy aging, delaying the progression of aging-related diseases, and the incidence of morbidity can greatly alleviate the pressure on individuals and society. Current research and exploration in the field of materials related to aging are expanding tremendously. Here, we present a summary of recent research in the field of nanomaterials relevant to aging. Some nanomaterials, such as silica nanomaterials (NMs) and carbon nanotubes, cause damage to the cells similar to aging processes. Other nanomaterials such as fullerenes and metalbased nanomaterials can protect the body from endogenous and exogenous harmful substances such as ROS by virtue of their excellent reducing properties. Another new type of nucleic acid nanomaterial, tetrahedral framework nucleic acids, works effectively against cell damage. This material selectively clears existing senescent cells in the tissue and thus prevents the development of the chronic inflammatory environment caused by senescent cells secreting senescence-associated secretory phenotype to the surroundings. We believe that nanomaterials have tremendous potential to advance the understanding and treatment of aging-related disorders, and today's research only represents the beginning stages.

随着老年人口比例的增加，越来越多的人患有与衰老相关的疾病。即使衰老不可避免，延长健康衰老的时间，延缓衰老相关疾病的进展，降低发病率，可以大大减轻个人和社会的压力。当前与老化相关的材料领域的研究和探索正在急剧扩大。在这里，我们总结了与老化相关的纳米材料领域的最新研究。一些纳米材料，如二氧化硅纳米材料 (NMs) 和碳纳米管，会对细胞造成类似于老化过程的损伤。其他纳米材料，如富勒烯和金属基纳米材料，凭借其优异的还原性能，可以保护身体免受内源性和外源性有害物质如 ROS 的侵害。另一种新型核酸纳米材料——四面体框架核酸，有效对抗细胞损伤。这种材料选择性地清除组织中现有的衰老细胞，从而防止由衰老细胞向周围分泌衰老相关分泌表型引起的慢性炎症环境的发展。我们相信纳米材料在促进对衰老相关疾病的理解和治疗方面具有巨大潜力，而今天的研究仅代表开始阶段。这种材料选择性地清除组织中现有的衰老细胞，从而防止由衰老细胞向周围分泌衰老相关分泌表型引起的慢性炎症环境的发展。我们相信纳米材料在促进对衰老相关疾病的理解和治疗方面具有巨大潜力，而今天的研究仅代表开始阶段。这种材料选择性地清除组织中现有的衰老细胞，从而防止由衰老细胞向周围分泌衰老相关分泌表型引起的慢性炎症环境的发展。我们相信纳米材料在促进对衰老相关疾病的理解和治疗方面具有巨大潜力，而今天的研究仅代表开始阶段。