In recent years, tetrahedral Framework Nucleic Acids(tFNAs) have become a hot topic in the field of DNA nanostructures because of their stable structures, nanoscale size, superior mechanical properties and convenient synthesis with high yield. tFNAs are considered promising drug delivery carriers because they can pass through the cellular membrane without any help and they have a good biocompatibility and biodegradability. Besides, they have rich modification sites, they can be modified by kinds of functional groups. The functionalization molecules can be modified on the vertexes, embedded between the double-stranded DNA of the tetrahedron edges, hanged on the edges, or encapsulated in the cage-like structure of the tetrahedron. The structure of tetrahedron can also be intelligently controlled through smart design, such as integrating DNA hairpin loop structure onto the edges. Nowadays, DNA tetrahedron will have a broader development prospect in the application of drug transport carriers and intelligent drug carriers. Therefore, DNA material is a new carrier material with great advantages and has a very broad application prospect in the construction of an intelligent drug transport system.

近年来，四面体骨架核酸（tFNAs）因其结构稳定、纳米级尺寸、优异的机械性能和合成方便且产率高而成为DNA纳米结构领域的热门话题。tFNAs 被认为是有前景的药物递送载体，因为它们可以在没有任何帮助的情况下穿过细胞膜，并且它们具有良好的生物相容性和生物降解性。此外，它们具有丰富的修饰位点，可以被各种官能团修饰。功能化分子可以在顶点上进行修饰，嵌入四面体边缘的双链DNA之间，悬挂在边缘上，或封装在四面体的笼状结构中。四面体的结构也可以通过智能设计进行智能控制，例如将 DNA 发夹环结构整合到边缘。如今，DNA四面体在药物转运载体和智能药物载体的应用中将有更广阔的发展前景。因此，DNA材料是一种具有很大优势的新型载体材料，在构建智能药物输送系统方面具有非常广阔的应用前景。