Reactive Skin Decontamination Lotion (RSDL®) is an FDA-approved skin decontamination kit carried by service members for removal and neutralisation of vesicants and nerve agents. The RSDL kit, comprised of a lotion-impregnated sponge, was shown to be the superior medical decontamination device for chemical warfare agent (CWA) exposure on intact skin. In the event of a chemical exposure situation (i.e. terrorism, battlefield) physical injuries are probable, and preservation of life will outweigh the risk associated with application of RSDL to compromised skin. The purpose of this study was to quantify the rate and quality of wound healing in epidermal skin wounds treated with RSDL in a porcine model. Degree of wound healing was assessed using bioengineering methods to include ballistometry, colorimetry, evaporimetry, and high-frequency ultrasonography. Clinical observation, histopathology and immunohistochemistry were also utilised. All pigs received four bilateral superficial abdominal wounds via a pneumatic dermatome on their ventral abdomen, then were treated with the following dressings over a seven-day period: RSDL sponge, petroleum based Xeroform® gauze, 3 M™ Tegaderm™ Film, and 3 M™ Tegaderm™ Foam. Two additional non-wounded sites on the flank were used as controls. Two groups of pigs were then evaluated for a 21- or 56-day time period, representing short- and long-term wound-healing progression. Our findings indicated RSDL had a negative impact on wound-healing progression at both 21 and 56 days post-injury. Wounds receiving RSDL demonstrated a decreased skin elasticity, significant transepidermal water loss, and altered skin colouration and thickness. In addition, the rate of wound healing was delayed, and return to a functional skin barrier was altered when compared to non-RSDL-treated wounds. In conclusion, wound management care and clinical therapeutic intervention plans should be established to account for a prolonged duration of healing in patients with RSDL-contaminated wounds.

中文翻译：

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在哥廷根minipig®模型中，反应性皮肤去污乳液（RSDL®）会损害伤口愈合。

活性皮肤去污剂（RSDL®）是FDA批准的由服务人员携带的皮肤去污剂套件，用于去除和中和发泡剂和神经毒剂。RSDL试剂盒由浸有乳液的海绵组成，被证明是在完整皮肤上暴露化学战剂（CWA）的上乘医疗净化设备。如果发生化学暴露（例如恐怖主义，战场），则很可能会造成身体伤害，并且挽救生命将超过将RSDL应用于受损皮肤的风险。这项研究的目的是量化在猪模型中用RSDL处理的表皮皮肤伤口的伤口愈合速度和质量。使用生物工程方法评估伤口的愈合程度，包括弹丸法，比色法，蒸发法，和高频超声检查。还利用了临床观察，组织病理学和免疫组织化学。所有猪的腹部均受到气动皮刀的四个双侧浅表腹部伤口，然后在7天的时间内用以下敷料进行处理：RSDL海绵，石油基Xeroform®纱布，3 M™Tegaderm™薄膜和3 M ™Tegaderm™泡沫。侧面的另外两个非受伤部位被用作对照。然后对两组猪进行21天或56天的评估，分别代表短期和长期的伤口愈合进程。我们的研究结果表明，RSDL在损伤后21天和56天对伤口愈合的进程有负面影响。接受RSDL的伤口表现出皮肤弹性降低，经皮表皮水分大量流失，皮肤颜色和厚度改变。此外，与未用RSDL处理的伤口相比，伤口的愈合速度有所延迟，并且恢复了功能性皮肤屏障的功能也有所改变。总之，应建立伤口管理护理和临床治疗干预计划，以解决RSDL污染伤口患者的治愈时间延长问题。