Endocrine disrupting chemicals (EDCs) are chemicals found in our environment that interrupt typical endocrine function. Some flame retardants (FRs) are EDCs as shown in their interaction with steroid and nuclear receptors. Humans are consistently exposed to flame retardants as they are used in everyday items such as plastics, clothing, toys, and electronics. Polybrominated diphenyl ethers were used as the major FR until 2004, when they were replaced by organophosphate flame retardants (OPFRs). Previous research in rodent models utilizing a commercial flame retardant mixture containing OPFRs reported alterations in anxiety-like behavior in the elevated plus maze (EPM) for rodents perinatally exposed to OPFRs. In the present study we utilize wild-type mice maternally exposed (gestational day 7 to postnatal day 14) to either an OPFR mixture of tris(1,3-dichloro-2-propyl), triphenyl phosphate, and tricresyl phosphate or a sesame seed oil vehicle. These mice were evaluated for anxiety-like behavior in adulthood on the open field test (OFT) and the light/dark box (LDB) as well as the EPM. Outcomes from the OFT and LDB indicate that males and females maternally exposed to OPFRs exhibit altered locomotor activity. Results of the EPM were sex-specific as we did not observe an effect in females; however, effects in males differed depending on exposure condition. Males maternally exposed to OPFRs exhibited an anxiolytic-like phenotype in contrast to their vehicle counterparts. This effect in perinatally OPFR-exposed males was not due to alterations in locomotor activity. Our research illustrates that there are sex- and exposure-dependent effects of perinatal OPFR exposure on adult locomotor and anxiety-like behaviors in a mouse model.

中文翻译：

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母亲暴露于有机磷阻燃剂会改变雄性和雌性成年后代的运动和焦虑样行为。

内分泌干​​扰化学物质 (EDC) 是在我们的环境中发现的干扰典型内分泌功能的化学物质。一些阻燃剂 (FR) 是 EDC，如它们与类固醇和核受体的相互作用所示。人类经常接触阻燃剂，因为它们用于塑料、服装、玩具和电子产品等日常用品。多溴二苯醚一直用作主要阻燃剂，直到 2004 年它们被有机磷酸酯阻燃剂 (OPFR) 取代。先前对使用含有 OPFR 的商用阻燃剂混合物的啮齿动物模型的研究报告称，围产期暴露于 OPFR 的啮齿动物在高架十字迷宫 (EPM) 中的焦虑样行为发生了改变。在本研究中，我们利用母体暴露（妊娠第 7 天至出生后第 14 天）的野生型小鼠暴露于 OPFR 混合物 tris(1, 3-二氯-2-丙基）、磷酸三苯酯和磷酸三甲苯酯或芝麻油载体。在露天试验 (OFT) 和明暗盒 (LDB) 以及 EPM 中评估这些小鼠成年后的焦虑样行为。OFT 和 LDB 的结果表明，母体暴露于 OPFRs 的雄性和雌性表现出改变的运动活动。EPM 的结果是性别特异性的，因为我们没有观察到对女性的影响；然而，对男性的影响因暴露条件而异。与载体对应物相比，母体暴露于 OPFRs 的雄性表现出抗焦虑样表型。围产期暴露于 OPFR 的男性的这种影响不是由于运动活动的改变。