OBJECTIVE The aim of this study was to evaluate the levels of caveolin-1 in thyroid follicular epithelial cells of papillary thyroid cancer, follicular thyroid cancer, and nonmalignant thyroid nodule benign follicular adenoma, as well as to explore the relationship between the levels of caveolin-1 and thyroid function. METHODS Thirty cases of papillary thyroid cancer, 10 cases of follicular thyroid cancer, 32 cases of nonmalignant thyroid nodule benign follicular adenoma, and 30 controls were enrolled in this study. Caveolin-1 expression in tissue specimens obtained from these cases was evaluated by immunohistochemistry and Western blotting. RESULTS Caveolin-1 expression in thyroid epithelial cells of patients with papillary thyroid cancer, particularly female patients, was significantly higher than that in patients with follicular thyroid cancer and nonmalignant thyroid nodule benign follicular adenoma (P < .005). Serum thyroid-stimulating hormone (TSH) levels in the caveolin-1-positive expression group were lower than that in the caveolin-1-negative expression group, and the lowest expression of caveolin-1 was detected in tissues of patients with Graves' disease. The serum TSH level was associated with caveolin-1 expression in thyroid epithelial cells. CONCLUSION Caveolin-1 may participate in regulating thyroid function and is a potential biomarker of follicular thyroid cancer.

中文翻译：

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Caveolin-1 的表达与人乳头状甲状腺癌患者的甲状腺功能有关。

目的 本研究旨在评估甲状腺乳头状癌、滤泡性甲状腺癌和非恶性甲状腺结节良性滤泡性腺瘤的甲状腺滤泡上皮细胞中caveolin-1的水平，并探讨caveolin-1水平与甲状腺滤泡素-1水平的关系。 1、甲状腺功能。方法 30例甲状腺乳头状癌、10例滤泡状甲状腺癌、32例非恶性甲状腺结节良性滤泡性腺瘤和30例对照纳入本研究。通过免疫组织化学和蛋白质印迹评估从这些病例获得的组织标本中的 Caveolin-1 表达。结果 乳头状甲状腺癌患者，尤其是女性患者甲状腺上皮细胞中 Caveolin-1 的表达，显着高于滤泡性甲状腺癌和非恶性甲状腺结节良性滤泡性腺瘤患者（P < .005）。Caveolin-1阳性表达组血清促甲状腺激素（TSH）水平低于caveolin-1阴性表达组，在Graves病患者组织中检测到caveolin-1表达最低. 血清TSH水平与甲状腺上皮细胞中caveolin-1的表达有关。结论 Caveolin-1可能参与调节甲状腺功能，是甲状腺滤泡癌的潜在生物标志物。在 Graves 病患者的组织中检测到 Caveolin-1 的最低表达。血清TSH水平与甲状腺上皮细胞中caveolin-1的表达有关。结论 Caveolin-1可能参与调节甲状腺功能，是甲状腺滤泡癌的潜在生物标志物。在 Graves 病患者的组织中检测到 Caveolin-1 的最低表达。血清TSH水平与甲状腺上皮细胞中caveolin-1的表达有关。结论 Caveolin-1可能参与调节甲状腺功能，是甲状腺滤泡癌的潜在生物标志物。