OBJECTIVE To investigate the protective effect of repaglinide on rat with atherosclerosis. METHODS Sprague Dawley (SD) rats were divided into control, model, repaglinide, and metformin groups. In addition to the normal group, rats were given intraperitoneal injection of streptozotocin and high-fat diet (HFD). Meanwhile, repaglinide or metformin was administrated to the treatment rats, respectively, for 4 weeks. Serum, plasma, liver, epididymal fat, and aorta thoracica were obtained to observe the protective effect of repaglinide on rat with atherosclerosis. RESULTS Compared to the control group, blood glucose was increased in the model group (P < .05), while it was decreased in the drug-administered groups. In addition, the levels of endothelin 1, TG, TC, low-density lipoprotein cholesterol, atherogenic index, liver index, and epididymal fat index were significantly increased, but the levels of high-density lipoprotein cholesterol, plasminogen activator inhibitor 1, and antiatherogenic index were decreased significantly in the model group compared to the control group (P < .05, respectively). And these effects were reversed by treatment with repaglinide (P < .05, respectively). CONCLUSION Our results suggested that repaglinide may regulate the formation of early atherosclerosis through the abovementioned mechanisms.

中文翻译：

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瑞格列奈对动脉粥样硬化大鼠模型中血糖、内皮功能、脂质代谢和炎症反应的影响。

目的探讨瑞格列奈对动脉粥样硬化大鼠的保护作用。方法 Sprague Dawley (SD) 大鼠分为对照组、模型组、瑞格列奈组和二甲双胍组。除正常组外，给予大鼠腹腔注射链脲佐菌素和高脂饮食（HFD）。同时，对治疗大鼠分别给予瑞格列奈或二甲双胍4周。采集血清、血浆、肝脏、附睾脂肪和胸主动脉，观察瑞格列奈对动脉粥样硬化大鼠的保护作用。结果与对照组相比，模型组血糖升高（P < .05），而给药组血糖降低。此外，内皮素1、TG、TC、低密度脂蛋白胆固醇、动脉粥样硬化指数、肝脏指数、与对照组相比，模型组的附睾脂肪指数和附睾脂肪指数显着升高，但高密度脂蛋白胆固醇、纤溶酶原激活物抑制剂1和抗动脉粥样硬化指数显着降低（分别P < .05）。瑞格列奈治疗逆转了这些影响（分别为 P < .05）。结论 我们的研究结果表明，瑞格列奈可能通过上述机制调节早期动脉粥样硬化的形成。