Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

中文翻译：

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严重的颞下颌关节功能异常在滑膜组织中过表达MMP-7和MMP-9。

基质金属蛋白酶（MMP）是组织酶，在重塑过程中（例如在炎症性疾病中）起着关键作用。MMP-7和MMP-9已被证明与细胞外基质稳态和关节盘重塑有关。这项研究的目的是确定使用免疫组织化学方法，MMP-7和MMP-9表达与严重的颞下颌关节功能障碍，特别是前盘移位而不减少（ADDwoR）的关系。因此，在测试组中收集了二十个人颞下颌滑膜，在对照组中收集了十个人。结果表明，对照组和测试组中检测到的MMP的形态计量和光密度测定分析存在统计学差异（P <0.001）。结论，