Abstract Mitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles of inter-organelle contact sites in lipid trafficking between different organelle membranes. Identification of Ups/PRELI proteins as lipid transfer proteins shuttling between the mitochondrial outer and inner membranes established a part of the molecular and structural basis of the still elusive intra-mitochondrial lipid trafficking.

中文翻译：

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线粒体中的脂质稳态

摘要 线粒体被外膜和内膜这两个膜包围，其脂质成分针对线粒体的适当功能和结构组织进行了优化。虽然一部分线粒体脂质，包括其特征脂质，磷脂酰乙醇胺和心磷脂，是在线粒体内合成的，但它们的前体脂质和其他脂质是从其他细胞器（主要是内质网）转运的。线粒体合成的脂质也重新分布在线粒体内和其他细胞器中。最近的研究指出了细胞器间接触位点在不同细胞器膜之间的脂质运输中的重要作用。