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The influence of Ca2+ and Zn2+ on the amyloid fibril formation by β-casein.
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200318143533 Jia Wang 1 , Jihua Liu 1 , Guangguang Du 1 , Yang An 1 , Chunfang Zhao 1 , Baohua Zeng 2
中文翻译:
Ca2 +和Zn2 +对β-酪蛋白形成淀粉样蛋白原纤维的影响。
更新日期:2020-10-16
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200318143533 Jia Wang 1 , Jihua Liu 1 , Guangguang Du 1 , Yang An 1 , Chunfang Zhao 1 , Baohua Zeng 2
Affiliation
Background: The amyloid fibril formation in different tissues or organs is related to amyloidosis. The Ca2+, Zn2+ and heparan sulfate (HS) are important elements and compositions in human body, which play a key role in regulating various physiological activities. Recently, there are increasing evidence suggest that they are closely linked to the amyloid fibril formation.
Objective: The effect of Ca2+ and Zn2+ on the amyloid fibril formation by β-casein was investigated in the absence and presence of HS, which was significantly to explore the relationship between the concentration changes of Ca2+ and Zn2+ and amyloid fibril formation.中文翻译:
Ca2 +和Zn2 +对β-酪蛋白形成淀粉样蛋白原纤维的影响。
背景:不同组织或器官中淀粉样蛋白原纤维的形成与淀粉样变性有关。Ca2 +,Zn2 +和硫酸乙酰肝素(HS)是人体中的重要元素和组成,在调节各种生理活动中起关键作用。最近,越来越多的证据表明它们与淀粉样蛋白原纤维的形成紧密相关。
目的:研究在不存在和存在HS的情况下,Ca2 +和Zn2 +对β-酪蛋白形成淀粉样蛋白原纤维的影响,这对于探讨Ca2 +和Zn2 +的浓度变化与淀粉样蛋白原纤维形成之间的关系具有重要意义。