Background: The amyloid fibril formation in different tissues or organs is related to amyloidosis. The Ca2+, Zn2+ and heparan sulfate (HS) are important elements and compositions in human body, which play a key role in regulating various physiological activities. Recently, there are increasing evidence suggest that they are closely linked to the amyloid fibril formation.

Objective: The effect of Ca2+ and Zn2+ on the amyloid fibril formation by β-casein was investigated in the absence and presence of HS, which was significantly to explore the relationship between the concentration changes of Ca2+ and Zn2+ and amyloid fibril formation.

中文翻译：

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Ca2 +和Zn2 +对β-酪蛋白形成淀粉样蛋白原纤维的影响。

背景：不同组织或器官中淀粉样蛋白原纤维的形成与淀粉样变性有关。Ca2 +，Zn2 +和硫酸乙酰肝素（HS）是人体中的重要元素和组成，在调节各种生理活动中起关键作用。最近，越来越多的证据表明它们与淀粉样蛋白原纤维的形成紧密相关。

目的：研究在不存在和存在HS的情况下，Ca2 +和Zn2 +对β-酪蛋白形成淀粉样蛋白原纤维的影响，这对于探讨Ca2 +和Zn2 +的浓度变化与淀粉样蛋白原纤维形成之间的关系具有重要意义。