Abstract

In this study, the insulin-like and insulin sensitising effects of the ellagitannins geraniin, corilagin, ellagic acid, gallic acid and Nephelium lappaceum rind extract in 3T3-L1 adipocytes was investigated. It was observed that non-toxic concentrations of geraniin and its metabolites (0.2–20 μM) and N. lappaceum extract (0.2–20 μg/mL) exhibited insulin-like properties in the absence of insulin and insulin-sensitising properties in the presence of insulin particularly with regards to glucose uptake in 3T3-L1 adipocytes. The compounds were further able to promote adipocyte differentiation and may be involved in the inhibition of lipolysis in 3T3-L1 adipocytes in the presence of insulin. However further study into the molecular mechanisms of action of these compounds need to be carried out to better understand the potential of these compounds/extracts to act as therapeutic agents for hyperglycaemia associated with diabetes mellitus and obesity.

摘要

在这项研究中，鞣花单宁的胰岛素样和胰岛素敏化影响geraniin，柯里拉京，鞣花酸，没食子酸和韶lappaceum果皮提取物在3T3-L1脂肪细胞进行了研究。据观察，geraniin的非毒性浓度和它的代谢物（0.2-20μM）和N. lappaceum提取物（0.2–20μg/ mL）在不存在胰岛素的情况下表现出类似胰岛素的特性，在存在胰岛素的情况下表现出胰岛素敏化的特性，特别是在3T3-L1脂肪细胞摄取葡萄糖方面。这些化合物还能够促进脂肪细胞分化，并且可能在胰岛素存在下参与3T3-L1脂肪细胞中脂解的抑制作用。然而，需要对这些化合物的分子作用机理进行进一步的研究，以更好地理解这些化合物/提取物作为与糖尿病和肥胖症相关的高血糖症的治疗剂的潜力。