Abstract

A new sesquiterpene pyridine alkaloid (1), along with four known compounds (2-5), were isolated from the stems and leaves of Euonymus fortunei. The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound 3 showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC₅₀ value of 1.20 ± 0.10 µM than the positive control ribavirin with an IC₅₀ value of 5.62 ± 0.49 µM.

中文翻译：

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一种从大叶黄杨（Euonymus fortunei）的茎和叶中提取的倍半萜吡啶生物碱

摘要

一种新的倍半萜吡啶生物碱（1），具有四个已知化合物（沿2 - 5），分离从茎叶扶芳藤。通过广泛的光谱分析（IR，UV，NMR，HRESIMS和ECD）确定了新结构。此外，化合物3的抗呼吸道合胞病毒（RSV）活性比阳性对照利巴韦林的IC ₅₀值为5.62±0.49 µM ，具有更强的抗呼吸道合胞病毒（RSV）活性，IC ₅₀值为1.20±0.10 µM。