ABSTRACT

Therapeutic macromolecules such as proteins are conventionally administered via bolus injection, an approach that presents significant limitations. Sustained-release biodegradable nano/microsphere depots, on the other hand, represent a more physiological delivery tool for biologics. Here, we focus on an emerging novel application of this technology, i.e., cytokine-encapsulated biodegradable microspheres as immune therapeutics. The overall pre-clinical experience, recent advances and the clinical potential of such formulations are discussed.

中文翻译：

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细胞因子包裹的可生物降解的微球用于免疫治疗。

摘要

诸如蛋白质之类的治疗性大分子通常通过大剂量注射来给药，这种方法存在明显的局限性。另一方面，缓释可生物降解的纳米/微球长效制剂代表了生物制剂更生理的递送工具。在这里，我们专注于这项技术的新兴应用，即细胞因子包裹的生物可降解微球作为免疫疗法。讨论了此类制剂的整体临床前经验，最新进展和临床潜力。