Human papilloma virus has a clearly demonstrated role in cervical and head and neck cancers, but viral etiology for other solid tumors is less well understood. To expand this area of research, we obtained and analyzed the immune receptor recombinations available from both blood and tumor samples, through mining of exome files produced from those sources, for 32 cancer types represented by the cancer genome atlas (TCGA). Among TCGA data sets, the recovery frequency for antiviral complementarity determining region-3 sequences (CDR3s), for T cell receptor-alpha and T cell receptor-beta, ranged from 0% to 21% of the patients, for the different cancer types, with breast, lung, pancreatic, and thymus cancers representing the highest of that range, particularly for tumor tissue resident T cells. In several cases, recovery of the antiviral CDR3s associated with distinct survival rates, and in all of these cases, the recovery of an antiviral CDR3 associated with a worse survival rate.

中文翻译：

---

确定Region-3序列的抗病毒T细胞受体互补性与较差的癌症结果相关：Pancancer分析。

人乳头瘤病毒在宫颈癌和头颈癌中具有明确的作用，但对其他实体瘤的病毒病因学知之甚少。为了扩展这一研究领域，我们通过挖掘从这些来源产生的外显子组文件，获得并分析了从血液和肿瘤样品中可获得的免疫受体重组，以32种癌症基因组图谱（TCGA）为代表。在TCGA数据集中，针对不同类型的癌症，T细胞受体α和T细胞受体β的抗病毒互补决定区3序列（CDR3）的恢复频率在0％至21％的患者中，乳腺癌，肺癌，胰腺癌和胸腺癌占该范围的最高值，特别是对于肿瘤组织中的T细胞而言。在某些情况下，