Objective

To evaluate the association between trabecular bone score (TBS) and new bone formation in ankylosing spondylitis (AS) patients, and to investigate whether TBS is independently associated with new bone formation.

Method

Sixty-eight patients with AS underwent spinal magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry of the lumbar spine to measure TBS and bone mineral density at baseline. Lateral radiographs of the cervical and lumbar spine (baseline and 2 years) were assessed for new bone formation (syndesmophyte formation and/or growth combined), and spinal MRIs were assessed for the presence or absence of fat metaplasia (FM) at the first to fourth lumbar vertebrae. The factors associated with new bone formation were analysed at the patient level and the vertebral level.

Results

New bone formation had developed in 17 patients (25%) at 2 year follow-up. Patients with new bone formation had a higher prevalence of FM and lower TBS at baseline than patients without new bone formation (p = 0.013 and p = 0.041). At the patient level, FM on MRI and low TBS (< 1.23) were significantly associated with new bone formation. At the vertebral level, new bone formation had developed in 25 out of 231 vertebrae (11%) after 2 years. Vertebrae with both FM on MRI and low TBS tended to have more new bone formation (p < 0.001). Syndesmophytes and low TBS (< 1.23) independently increased the risk of new bone formation at the level of individual vertebrae.

Conclusion

At both patient and individual vertebral levels, low TBS was associated with new bone formation independently of FM on MRI.

中文翻译：

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在强直性脊柱炎患者中，小梁骨评分值与新骨形成相关，独立于脊柱磁共振成像上的脂肪化生。

目的

评估强直性脊柱炎（AS）患者的小梁骨评分（TBS）与新骨形成之间的关联，并调查TBS是否与新骨形成独立相关。

方法

对68例AS患者进行了脊柱磁共振成像（MRI）和腰椎双能X线骨密度仪，以测量基线时的TBS和骨矿物质密度。评估颈椎和腰椎的侧位X线照片（基线和2年）是否有新的骨形成（骨赘形成和/或生长相结合），并且在第一至第一天就评估了脊柱MRI是否存在脂肪化生（FM）。第四腰椎。在患者水平和椎骨水平分析了与新骨形成相关的因素。

结果

在两年的随访中，有17例患者（25％）出现了新的骨形成。与没有新骨形成的患者相比，有新骨形成的患者在基线时的FM患病率较高，而TBS较低（p = 0.013和p = 0.041）。在患者水平，MRI FM和低TBS（<1.23）与新骨形成显着相关。在椎体水平上，两年后，在231块椎骨中，有25块（11％）形成了新的骨形成。MRI上的FM和低TBS的椎骨倾向于具有更多的新骨形成（p <0.001）。同伴植物和低TBS（<1.23）独立地增加了单个椎骨水平上新骨形成的风险。

结论

在患者和个体椎骨水平上，低TBS与新骨形成相关，而与MRI上的FM无关。