Abstract

A detailed review to analyze the anti ulcer proton pump inhibitor (PPI) drugs, particularly for determination of their concentration percentage (assay) by analytical methods developed on analytical instruments i.e., UV visible Spectrophotometer, High Performance Liquid Chromatography, Ultra Performance Liquid Chromatography, and Hyphenated techniques. The review includes literature survey of PPI drugs namely omeprazole (OPZ), lansoprazole (LPZ), pantoprazole (PPZ) rabeprazole (RPZ), dexlansoprazole (DLPZ), esomeprazole (EPZ), dexrabeprazole (DRPZ), ilaprazole (IPZ), and tenatoprazole (TPZ). The examined literature survey addressed chromatographic (HPLC and UPLC) and UV visible spectrophotometric methods with LC-MS/MS methods used in pure forms, pharmaceutical formulations, and human plasma and other biological fluids for their estimation. In case of validation parameters mostly Linearity, Recovery study, LOD and LOQ was considered and mentioned.

摘要

详细回顾分析抗溃疡质子泵抑制剂 (PPI) 药物，特别是通过分析仪器开发的分析方法确定其浓度百分比（测定），如紫外可见分光光度计、高效液相色谱、超高效液相色谱和连字符技术。该综述包括对 PPI 药物的文献调查，即奥美拉唑 (OPZ)、兰索拉唑 (LPZ)、泮托拉唑 (PPZ)、雷贝拉唑 (RPZ)、右兰索拉唑 (DLPZ)、埃索美拉唑 (EPZ)、右雷贝拉唑 (DRPZ)、艾普拉唑 (IPZ) 和替那拉唑(TPZ)。经审查的文献调查涉及色谱法（HPLC 和 UPLC）和紫外可见分光光度法和 LC-MS/MS 方法，用于纯形式、药物制剂、人血浆和其他生物流体的估计。