Whole-genome sequencing analyses have provided important data and information on the repertoire of resistance genes in several bacterial species. This study examined to what extent the antimicrobial resistance genes found in a set of whole-genome-sequenced Salmonella Enteritidis strains from Brazil correlated with the phenotypic antimicrobial resistance possibly related to these genes. The genotypic resistance data from the strains studied were compared with publicly available data from strains isolated in other countries. The genotypic resistance profiles were accessed on the NCBI Pathogen Detection website, and the phenotypic resistance profiles were determined by the disk diffusion technique according to the Clinical and Laboratory Standards Institute guidelines. Fourteen of the 256 sequenced strains presented antimicrobial resistance genes, with the highest prevalence of resistance genes to aminoglycosides—with 16 genes detected in seven strains—not only in Brazilian strains but also in the strains from other parts of the world. The strongest correlation between phenotypic and genotypic resistance was found for tetracycline (75%). The genotypic and phenotypic profiles of the S. Enteritidis strains studied only partially matched, and they diverged in some antimicrobial classes more strongly than in other classes. The advances on whole-genome sequencing analyses associated with a better understanding of the correlation between phenotypic and genotypic resistance data may improve this powerful tool for antimicrobial resistance prediction.

中文翻译：

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来自巴西的肠炎沙门氏菌血清型肠炎沙门氏菌的表型和基因型抗菌素耐药性之间的部分相关性。

全基因组测序分析提供了关于几种细菌物种中抗性基因库的重要数据和信息。这项研究检查了在一组全基因组测序的沙门氏菌中发现的抗菌素耐药基因的程度来自巴西的肠炎菌株与可能与这些基因有关的表型抗菌素耐药性相关。将研究菌株的基因型抗性数据与在其他国家分离的菌株的公开数据进行比较。可在 NCBI 病原体检测网站上访问基因型抗性概况，并根据临床和实验室标准协会的指南通过圆盘扩散技术确定表型抗性概况。256 株测序菌株中有 14 株具有抗菌素耐药性基因，其中氨基糖苷类抗生素耐药基因的流行率最高——在 7 株菌株中检测到 16 个基因——不仅在巴西菌株中，而且在世界其他地区的菌株中也是如此。四环素的表型和基因型抗性之间的相关性最强（75%）。的基因型和表型谱所研究的肠炎沙门氏菌菌株仅部分匹配，并且它们在某些抗菌类别中的差异比其他类别中的更强烈。与更好地理解表型和基因型耐药性数据之间的相关性相关的全基因组测序分析的进展可能会改进这一强大的抗菌素耐药性预测工具。