Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-β-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.

中文翻译：

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Plumbagin通过抑制p300组蛋白乙酰转移酶活性来抑制肺纤维化。

特发性肺纤维化（IPF）是一种慢性纤维化间质性肺疾病，与恶性肿瘤的预后差。IPF的病因尚不清楚，并且迄今为止尚无有效的治疗方法。在这项研究中，从玫瑰花根提取物中分离出的天然化合物plumbagin对p300抑制活性进行了筛选。Plumbagin特异性抑制p300对组蛋白乙酰转移酶的活性。铅霉素治疗可显着抑制转化生长因子-β诱导的纤维化靶基因表达和成纤维细胞系增殖。此外，李白蛋白显着抑制博来霉素诱导的小鼠肺纤维化。综上所述，这些数据证明了李白瓜素对肺纤维化的抑制作用及其作为IPF治疗剂的希望。