Streptococcus anginosus is an often overlooked and understudied emerging pathogen inhabiting many areas of the human body. Through our sequencing of S. anginosus strains isolated from the female bladder microbiota, we detected numerous prophage sequences. Bioinformatic analysis of these sequences identified 17 distinct groups of S. anginosus prophages. The majority of these phages exhibit no sequence homology to previously characterized temperate or virulent phage sequences, indicating an unexplored diversity of Streptococcus phages. By culturing these bacterial isolates, we confirmed that the prophages of five of these groups are capable of induction. One of these putative phages was imaged, the first such evidence of an S . anginosus virus-like particle; it exhibits morphological characteristics of siphoviruses.

中文翻译：

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泌尿道咽峡炎链球菌前噬菌体的表征和自发诱导。


咽峡炎链球菌是一种经常被忽视和研究不足的新兴病原体，存在于人体的许多部位。通过对从女性膀胱微生物群中分离出来的咽峡炎链球菌菌株进行测序，我们检测到了许多原噬菌体序列。对这些序列进行生物信息分析，鉴定出 17 个不同的咽峡链球菌原噬菌体组。这些噬菌体中的大多数与先前表征的温和或强毒噬菌体序列没有序列同源性，表明链球菌噬菌体具有未经探索的多样性。通过培养这些细菌分离株，我们证实其中五个组的原噬菌体能够诱导。其中一个假定的噬菌体被成像，这是S的第一个此类证据。咽峡炎病毒样颗粒；它表现出管状病毒的形态特征。