Background: To investigate the associations of Single Nucleotide Polymorphisms (SNPs) in the VIPR2 and ZMAT4 genes with high myopia in a Han Chinese population.Materials and Methods: In this case-control genetic association study comprising 193 high myopia participants and 135 normal emmetropic controls from a Han Chinese population, 15 SNPs from the VIPR2 and ZMAT4 genes were selected for genotyping based on previous studies. Allelic frequencies of the SNPs and haplotypes were compared for association with high myopia and axial length (AL).Results: RS885863 (G-reference/A-effect) and RS7829127 (A-reference/G-effect) were significantly associated with high myopia (OR = 1.832, P = .045; OR = 0.539, P = .023 respectively). The associations of RS885863 with high myopia were observed under the dominant (GA+AA: OR = 1.972, P < .05) and co-dominant models (Heterozygous GA: OR = 1.874; Homozygous AA: OR = 5.310; P < .05) against GG (reference). The mean AL of GG was 25.94 mm, compared with that in GA and AA of 26.64 mm and 27.48 mm respectively. The associations of RS7829127 with high myopia were observed under the dominant (AG+GG: OR = 0.512, P < .05) and co-dominant models (Heterozygous AG: OR = 0.524; Homozygous GG: OR = 0.307; P < .05) against AA (reference). The mean AL of AA was 26.35 mm, compared with that in AG and GG of 25.62 mm and 25.17 mm respectively. The importance of RS885863 and RS7829127 were also highlighted by their being the constituent SNPs in the haplotypes (ACGA, P = .002; and GA, P = .008 respectively) that were significantly associated with high myopia.Conclusions: Our findings agree that RS885863 from VIPR2 and RS7829127 from ZMAT4 are significantly associated with high myopia in a Han Chinese population.

中文翻译：

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VIPR2和ZMAT4与高度近视相关。

背景：研究汉族人群VIPR2和ZMAT4基因中的单核苷酸多态性（SNPs）与高度近视的关系。材料与方法：在本病例对照遗传关联研究中，包括193名高度近视参与者和135名正常正视对照者根据先前的研究，从汉族人群中选择了VIPR2和ZMAT4基因的15个SNP进行基因分型。比较了SNP和单倍型的等位基因频率与高度近视和轴距（AL）的相关性。结果：RS885863（G参照/ A效应）和RS7829127（A参照/ G效应）与高度近视显着相关（或分别为1.832，P = .045；或= 0.539，P = .023）。在显性（GA + AA：OR = 1.972，P <。）下观察到RS885863与高度近视相关。05）和针对GG（参考）的共同主导模型（杂合子GA：OR = 1.874;纯合子AA：OR = 5.310; P <.05）。GG的平均AL为25.94mm，而GA和AA的平均AL分别为26.64mm和27.48mm。在显性模型（AG + GG：OR = 0.512，P <.05）和共显性模型（杂合子AG：OR = 0.524;纯合子GG：OR = 0.307; P <.05）下观察到RS7829127与高度近视的关联）与AA（参考）相对应。AA的平均AL为26.35mm，而AG和GG的平均AL分别为25.62mm和25.17mm。RS885863和RS7829127的重要性也得到了强调，因为它们是高度近视显着相关的单体型中的组成SNP（分别为ACGA，P = 0.002和GA，P = 0.008）。