Differences in the gene expression profiles in resident macrophages (in particular, Kupffer cells) and monocytes were revealed. However, these differences in gene expression profiles do not allow considering resident liver macrophages as purely M2 macrophages and monocytes as purely M1 macrophages. At the same time, a significant number of the genes upregulated in Kupffer cells are associated with normal regulation of liver functions ( Arg 1 , Flt , iNOs , and Kng ). In monocytes, the expression of genes Alox15 , Alox12 , Tlr2 , Tlr4 , Tlr7 , and Tlr8 (typical functional genes of macrophages) was also upregulated in comparison with Kupffer cells.

中文翻译：

---

枯否细胞和单核细胞中调节基因的表达分析

揭示了常驻巨噬细胞（特别是库普弗细胞）和单核细胞中基因表达谱的差异。然而，基因表达谱的这些差异不允许将常驻肝脏巨噬细胞视为纯粹的 M2 巨噬细胞，将单核细胞视为纯粹的 M1 巨噬细胞。同时，库普弗细胞中大量上调的基因与肝功能（Arg 1 、Flt 、iNOs 和 Kng ）的正常调节有关。在单核细胞中，与 Kupffer 细胞相比，基因 Alox15、Alox12、Tlr2、Tlr4、Tlr7 和 Tlr8（巨噬细胞的典型功能基因）的表达也上调。