Rat model of severe contusion spinal cord injury was used to study the effect of single intravenous and intraspinal injection of human umbilical cord blood mononuclear cells on the restoration of motor function of the hind limbs. Recovery of the motor function of the hind limbs was assessed using load tests and open-field test according to BBB scale. Cell injection via both routes significantly improved ( p ≤0.05) the recovery of the motor function of the hind limbs by 35-40% relative to the level of “self-recovery”; the effects of intravenous andintraspinal administration did not differ significantly.

中文翻译：

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人脐血单个核细胞全身和局部细胞治疗对严重脊髓损伤大鼠的疗效比较

采用严重挫伤性脊髓损伤大鼠模型，研究单次静脉和椎管内注射人脐血单个核细胞对后肢运动功能恢复的影响。根据 BBB 量表，使用负荷试验和旷场试验评估后肢运动功能的恢复。两种途径的细胞注射均显着改善（p≤0.05）相对于“自我恢复”水平35-40%的后肢运动功能恢复；静脉内和椎管内给药的效果没有显着差异。