17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer's disease (AD), and in hormone‐dependent cancer. The objective of this review was to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.

中文翻译：

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朋友还是敌人？17β-HSD10及其在人类健康或疾病中的作用的综述。

17β-羟基类固醇脱氢酶（17β-HSD10）是一种多功能的人类酶，在结构上以及在许多代谢途径中起着重要的作用。这种线粒体酶在神经系统的代谢，发育和衰老中具有重要的功能，参与神经甾体的稳态，尤其是与雌二醇有关，其变化使其成为神经退行性病理的重要组成部分。因此，这些作用表明17β-HSD10可能是神经退行性疾病（包括阿尔茨海默氏病（AD））和激素依赖性癌症的可能药物治疗靶标。这篇综述的目的是提供有关17β-HSD10的生理功能和病理作用及其活性调节剂的概述。