The levels of monoamines and their metabolites in the brain structures of adult Wistar rats subjected to post-weaning social isolation for 2 and 3 months were analyzed by HPLC with electrochemical detection. We have previously shown that these rats consistently demonstrate increased aggressiveness and, as a rule, impairment of short-term habituation. Two-monthlong social isolation was accompanied by a reduction in serotonin content and its increased turnover judging from the 5-HIAA/5-HT ratio in the hippocampus; three-month-long isolation was associated with increased levels of serotonin and reduction in its turnover in the amygdala. At this term, the level of dopamine metabolite 3-methoxytyramine tended to increase in the amygdala. In the frontal cortex, a tendency to a decrease in 5-HT level was found. These findings suggest that more prolonged post-weaning social isolation is accompanied by reorganization of neural networks in the brain cortex, which can serve as the pathophysiological basis for psychoemotional disorders.

中文翻译：

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2、3个月社会隔离大鼠脑结构中单胺及其代谢物的含量

断奶后社会隔离 2 个月和 3 个月的成年 Wistar 大鼠脑结构中单胺及其代谢物的水平通过 HPLC 和电化学检测进行分析。我们之前已经表明，这些大鼠始终表现出攻击性增加，并且通常会损害短期习惯。两个月的社会隔离伴随着血清素含量的减少和海马体 5-HIAA/5-HT 比值的增加；长达三个月的隔离与血清素水平升高和杏仁核中其周转减少有关。此时，杏仁核中多巴胺代谢物 3-甲氧基酪胺的水平趋于增加。在额叶皮层中，发现 5-HT 水平有降低的趋势。