We performed a morphometric analysis of mesenteric lymph nodes in rats with breast cancer induced by administration of N-methyl-N-nitrosourea. The volume of the paracortical zone and the number of mature plasma cells in the medullary sinuses were increased and the volume of lymphoid nodules with germinal centers and the number of macrophages were decreased in the group with tumor resection and chemotherapy in comparison with untreated rats with breast cancer. In rats receiving fragmented human double-stranded DNA in combination with adjuvant therapy, the volume of marginal and medullary sinuses and the number of small lymphocytes and macrophages in the paracortical zone increased in comparison with the group receiving chemotherapy without DNA preparation; the volume of lymphoid nodules with germinal centers returned to the level observed in the intact group; the volume of medullary substance and proliferative activity of cells in the germinal centers and medullary substance decreased, the number of mature plasma cells returned to normal in the medullary substance and decreased in the medullary sinuses.

中文翻译：

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双链DNA片段化治疗实验性乳腺癌大鼠肠系膜淋巴结形态学研究

我们对施用 N-甲基-N-亚硝基脲诱导的乳腺癌大鼠的肠系膜淋巴结进行了形态计量学分析。与未治疗的乳腺大鼠相比，肿瘤切除和化疗组皮质旁区体积和髓窦成熟浆细胞数量增加，具有生发中心的淋巴结节体积和巨噬细胞数量减少癌症。在接受片段化人双链 DNA 联合辅助治疗的大鼠中，与未制备 DNA 的化疗组相比，边缘和髓窦的体积以及皮质旁区小淋巴细胞和巨噬细胞的数量增加；具有生发中心的淋巴结节的体积恢复到完整组中观察到的水平；生发中心、髓质髓质体积及细胞增殖活性下降，髓质内成熟浆细胞数量恢复正常，髓窦内成熟浆细胞数量减少。