Morphometric analysis of structural and functional changes in the human mesenteric lymph nodes during aging revealed the development of fibrous connective tissue, fragmentation of the lymphoid parenchyma, the absence of follicles with germinal centers, and a decrease in the level of lymphocyte proliferation, which was confirmed by the absence of Ki-67 + cells. The paracortical zone lacked CD4 + T helpers that regulate both cellular and humoral immunity. High content of plasma cells and eosinophilic granulocytes in the medullary cords and sinuses reflects the development of autoimmune processes associated with a decrease in the number of regulatory T lymphocytes. The development of fibrous connective tissue in the sinus system complicates lymph flow through the lymph node and impairs lymph filtration.

中文翻译：

---

衰老过程中人类肠系膜淋巴结的结构和功能变化

人类肠系膜淋巴结在衰老过程中的结构和功能变化的形态学分析显示纤维结缔组织的发育、淋巴实质的碎裂、具有生发中心的滤泡的缺失以及淋巴细胞增殖水平的降低，这已得到证实由于缺乏 Ki-67 + 细胞。副皮质区缺乏调节细胞免疫和体液免疫的 CD4 + T 辅助细胞。髓索和鼻窦中浆细胞和嗜酸性粒细胞的高含量反映了与调节性 T 淋巴细胞数量减少相关的自身免疫过程的发展。窦系统中纤维结缔组织的发育使通过淋巴结的淋巴流复杂化并损害淋巴过滤。