Reduced expression of the key regulator of cardiac metabolism, transcription factor PPARα, in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferentiated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed.

中文翻译：

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细胞再生过程中的能量代谢：关注 PPARα

通过实时定量 PCR 检测到心脏代谢的关键调节因子转录因子 PPARα 在冠心病和心力衰竭患者的耳廓手术样本中表达降低。这些变化表明该因子的活性降低，能量代谢从氧化磷酸化转变为去分化细胞典型的糖酵解。电子显微镜显示去分化的心肌细胞具有拆卸的收缩装置和无组织的肌节。在心力衰竭患者的检查标本中，发现严重的心肌纤维化。