Male BALB/с mice were intravenously infected with Mycobacterium tuberculosis H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine liposomes), INH, or a combination of LEDZ with INH was started. The doses of LEDZ (liposome suspension) and INH were 0.025 ml/10 g body weight and 5 mg/kg body weight, respectively. All the substances were administered 2 times a week via inhalation or intraperitoneally (a total of 40 doses). We studied the number and the size of tuberculous granulomas, the size of destruction foci and inflammatory infiltrates in the lungs and liver, the amount of fibrous connective tissue, and the dynamic of these parameters. LEDZ+INH inhalations were most effective by the therapeutic ratios in comparison with inhalation and intraperitoneal injections of INH.

中文翻译：

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脂质体包封右旋糖苷治疗实验性结核病小鼠肺和肝脏的结构变化

用结核分枝杆菌 H37Rv（0.5 ml 的 2 周培养物）静脉内感染雄性 BALB/с 小鼠。一个月后，开始使用脂质体包裹的右旋糖酐（LEDZ，异烟酸酰肼 (INH) 和包裹在磷脂酰胆碱脂质体中的 40 kDa 氧化葡聚糖的结合物）、INH 或 LEDZ 与 INH 的组合进行治疗。LEDZ（脂质体悬浮液）和 INH 的剂量分别为 0.025 ml/10 g 体重和 5 mg/kg 体重。所有物质每周通过吸入或腹膜内给药2次（共40剂）。我们研究了结核性肉芽肿的数量和大小、肺和肝脏中破坏灶和炎症浸润的大小、纤维结缔组织的数量以及这些参数的动态。