The effects of acclimatization to middle attitude hypoxia on the resistance to acute emotional stress were studied on the model of posttraumatic stress disorder in rats. Anxyolitic, but not anxiogenic effect was observed in acclimatized rats. However, acclimatized rats with posttraumatic stress disorder were characterized by hypofunction of the pituitary—adrenocortical axis, which is typical of this pathology, and reduction in corticosterone/dehydroepiandrosterone ratio. At the neuroendocrine level, up-regulation of glucocorticoid receptors and a decrease in the level of corticotropin-releasing hormone in the hippocampus were revealed. The observed modifications of regulatory mechanisms can underlie hypofunction of the pituitary—adrenocortical axis. It was concluded that acclimatization to middle attitude hypoxia masks behavioral symptoms of posttraumatic stress disorder, but does not alter its pathogenetic neuroendocrine mechanisms.

中文翻译：

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适应中等态度缺氧掩盖了实验性创伤后应激障碍的症状，但不影响其发病机制

在大鼠创伤后应激障碍模型上研究了适应中等态度缺氧对急性情绪应激抵抗能力的影响。在适应环境的大鼠中观察到抗焦虑作用，但没有观察到产生焦虑的作用。然而，患有创伤后应激障碍的驯化大鼠的特征是垂体 - 肾上腺皮质轴功能减退，这是这种病理的典型特征，以及皮质酮/脱氢表雄酮比率降低。在神经内分泌水平，糖皮质激素受体的上调和海马中促肾上腺皮质激素释放激素的水平降低。观察到的调节机制的改变可能是垂体 - 肾上腺皮质轴功能减退的基础。