We studied the effect of peptide drugs deltalicin and Semax on lipid metabolism disturbances in diabetes mellitus. Diabetes mellitus was modeled by single injection of streptozotocin (45 mg/kg) and rats with blood glucose ≥12 mmol/liter were selected for the further experiments. Deltalicin in a dose 100 μg/kg and Semax in a dose 200 μg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. Deltalicin produced more potent effect on lipid metabolism in rats with diabetes mellitus than sulodexide and Semax, which manifested in a significant decrease in total cholesterol and LDL concentration and index of atherogenicity.

中文翻译：

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肽类药物对糖尿病脂质代谢紊乱的纠正

我们研究了肽类药物 deltalicin 和 Semax 对糖尿病脂质代谢紊乱的影响。通过单次注射链脲佐菌素（45 mg/kg）模拟糖尿病，并选择血糖≥12 mmol/L的大鼠进行进一步实验。Deltalicin 100 μg/kg 剂量和 Semax 200 μg/kg 剂量以及舒洛地昔校正的脂质代谢紊乱：总胆固醇、甘油三酯、低密度脂蛋白的含量、致动脉粥样硬化指数降低和高密度脂蛋白浓度增加。Deltalicin 对糖尿病大鼠的脂质代谢产生比 sulodexide 和 Semax 更有效的作用，表现为总胆固醇和 LDL 浓度以及致动脉粥样硬化指数的显着降低。