Cell-cell adhesion molecules have critically important roles in the early events of reproduction including gamete transport, sperm-oocyte interaction, embryonic development, and implantation. Major adhesion molecules involved in reproduction include cadherins, integrins, and disintegrin and metalloprotease domain-containing (ADAM) proteins. ADAMs on the surface of sperm adhere to integrins on the oocyte in the initial stages of sperm-oocyte interaction and fusion. Cadherins act in early embryos to organize the inner cell mass and trophectoderm. The trophoblast and uterine endometrial epithelium variously express cadherins, integrins, trophinin, and selectin, which achieve apposition and attachment between the elongating conceptus and uterine epithelium before implantation. An overview of the major cell-cell adhesion molecules is presented and this is followed by examples of how adhesion molecules help shape early reproductive events. The argument is made that a deeper understanding of adhesion molecules and reproduction will inform new strategies that improve embryo survival and increase the efficiency of natural mating and assisted breeding in cattle.

中文翻译：

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配子转运，受精，早期胚胎发育和植入作用在牛妊娠中的粘附分子：综述。

细胞-细胞粘附分子在生殖的早期事件中具有至关重要的作用，包括配子转运，精子-卵母细胞相互作用，胚胎发育和植入。与繁殖有关的主要粘附分子包括钙粘着蛋白，整联蛋白，双整合蛋白和含金属蛋白酶域的蛋白质（ADAM）。在精子-卵母细胞相互作用和融合的初始阶段，精子表面的ADAM粘附在卵母细胞上的整联蛋白上。钙黏着蛋白在早期胚胎中起作用，以组织内部细胞团和滋养外胚层。滋养细胞和子宫内膜上皮以多种方式表达钙粘着蛋白，整联蛋白，肌钙蛋白和选择蛋白，它们在植入前可在延伸的子宫和子宫上皮之间形成并置。介绍了主要的细胞-细胞粘附分子的概况，然后是粘附分子如何帮助塑造早期生殖事件的例子。有观点认为，对粘附分子和繁殖的更深入了解将为提高胚胎存活率，提高牛自然交配和辅助育种效率的新策略提供参考。