We sought evidence on quantifiable offspring outcomes, including problems, needs and strengths, associated with their experience of major parental psychiatric disorder(s), focusing on schizophrenia, affective illnesses and personality disorder(s). We were motivated by the absence of any systematic exploration of the needs of offspring of parents in secure hospitals. Seven electronic databases were searched to identify systematic reviews of studies quantifying offspring outcomes when a parent, or parent surrogate, has major psychiatric disorder(s). Our search (updated in February 2018) identified seven high-quality reviews, which incorporated 291 unique papers, published in 1974–2017. The weight of evidence is of increased risk of poor offspring outcomes, including psychiatric disorder and/or behavioural, emotional, cognitive or social difficulties. No review explored child strengths. Potential moderators and mediators examined included aspects of parental disorder (eg, severity), parent and child gender and age, parenting behaviours, and family functioning. This clinical review is the first review of systematic reviews to focus on quantifiable offspring problems, needs or strengths when a parent has major psychiatric disorder(s). It narratively synthesises findings, emphasising the increased risk of offspring problems, while highlighting limits to what is known, especially the extent to which any increased risk of childhood problems endures and the extent to which aspects of parental disorder moderate offspring outcomes. The absence of the reviews’ consideration of child strengths and protective factors limits opportunity to enhance offspring resilience.

中文翻译：

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当父母经历一种或多种主要精神疾病时，后代的结果：临床回顾。

我们寻找可量化的后代结果的证据，包括与他们的主要父母精神疾病经历相关的问题、需求和优势，重点关注精神分裂症、情感疾病和人格障碍。我们的动机是缺乏对安全医院中父母子女的需求进行任何系统的探索。检索了七个电子数据库，以确定当父母或父母代理人患有严重精神疾病时量化后代结果的研究的系统评价。我们的搜索（于 2018 年 2 月更新）确定了 7 篇高质量评论，其中包含 1974 年至 2017 年发表的 291 篇独特论文。有证据表明，后代不良结局的风险增加，包括精神障碍和/或行为、情感、认知或社交困难。没有评论探讨儿童的优势。研究的潜在调节因素和中介因素包括父母障碍（例如严重程度）、父母和孩子的性别和年龄、养育行为和家庭功能等方面。本临床综述是首次系统综述，重点关注父母患有严重精神疾病时后代的可量化问题、需求或优势。它叙述性地综合了研究结果，强调后代问题风险增加，同时强调已知的局限性，特别是儿童问题风险增加的持续程度以及父母疾病的哪些方面调节后代结果的程度。审查缺乏对儿童优势和保护因素的考虑，限制了增强后代复原力的机会。