Introduction: Human papillomavirus (HPV) are the causative agent of mucosal neoplasia. Both cervical, anal and oropharyngeal cancers incidence is constantly increasing, making the HPV infection, a significant worldwide concern. Together, the CD8+ T cytotoxic cell-mediated response and the HPV-specific antibody response control most of the HPV infections before the development of cancers.Areas covered: We searched the MEDLINE and EMBASE databases and identified 228 eligible studies from 1987 to 2019 which examines both naturally acquired and vaccine induced humoral immunity against HPV infection in female and male subjects from worldwide origin. Herein, we synthesize current knowledge on the features of systemic and mucosal humoral immunity against HPV. We discuss the issues of the balance between the viral clearance or the escape to the host immune response, the differences between natural and vaccine-induced HPV-specific antibodies and their neutralizing capability. We also discuss the protection afforded after natural infection or following prophylactic vaccination.Expert opinion: Understanding the antibody response induced by HPV infection has led to the design of first-generation prophylactic vaccines. Now, prophylactic vaccination induces protective and long-lasting antibody response which would also strengthened the natural moderate humoral response in people previously exposed to the virus.

中文翻译：

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天然和疫苗诱导的B细胞对人乳头瘤病毒的全身和粘膜体液免疫。

简介：人乳头瘤病毒（HPV）是粘膜瘤形成的病因。子宫颈癌，肛门癌和口咽癌的发病率都在不断增加，这使得HPV感染成为全世界关注的重要问题。CD8 + T细胞毒性细胞介导的反应和HPV特异性抗体反应共同控制了癌症发生前的大多数HPV感染。研究范围：我们检索了MEDLINE和EMBASE数据库，确定了1987年至2019年的228项合格研究，天然获得的疫苗和疫苗诱导的针对来自世界各地的女性和男性受试者的HPV感染的体液免疫。本文中，我们综合了针对HPV的全身和粘膜体液免疫功能的当前知识。我们讨论了病毒清除或逃逸到宿主免疫反应之间的平衡，天然和疫苗诱导的HPV特异性抗体之间的差异及其中和能力之间的平衡问题。我们还讨论了自然感染或预防性接种疫苗后提供的保护。专家意见：了解由HPV感染引起的抗体反应已导致设计了第一代预防性疫苗。现在，预防性疫苗接种可诱导保护性和持久性抗体反应，这也将增强以前接触该病毒的人的自然适度的体液反应。我们还讨论了自然感染或预防性接种疫苗后提供的保护。专家意见：了解由HPV感染引起的抗体反应已导致设计了第一代预防性疫苗。现在，预防性疫苗接种可诱导保护性和持久性抗体反应，这也将增强以前接触该病毒的人的自然适度的体液反应。我们还讨论了自然感染或预防性接种疫苗后提供的保护。专家意见：了解由HPV感染引起的抗体反应已导致设计了第一代预防性疫苗。现在，预防性疫苗接种可诱导保护性和持久性抗体反应，这也将增强以前接触该病毒的人的自然适度的体液反应。