ABSTRACT

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.

中文翻译：

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关于LARP1功能的争议

 抽象的

近年来，RNA 结合蛋白 LARP1 因其在 mTOR 信号级联中的作用及其对末端寡嘧啶 (TOP) mRNA 翻译的调节而引起了人们的兴趣。矛盾的是，一些科学家表明 LARP1 抑制 TOP 翻译，而另一些科学家则表明 LARP1 激活它。在这里，我们提出了该领域四位领先科学家的观点，以讨论这些和其他相互矛盾的发现。