In vitro Biological Tests as the First Tools To Validate Magnetic Nanotheranostics for Colorectal Cancer Models.,ChemMedChem

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In vitro Biological Tests as the First Tools To Validate Magnetic Nanotheranostics for Colorectal Cancer Models.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-05-04 , DOI: 10.1002/cmdc.202000119
María Julia Martín _{1,

2} , Claudia Gentili ₂ , Verónica Lassalle ₁

Affiliation

Colorectal cancer (CRC) remains a leading cause of cancer death. Nanotechnology has focused on reaching more effective treatments. In this concern, magnetic nanoparticles (MNPs) have been studied for a wide range of biomedical applications related to CRC, such as diagnostic imaging, drug delivery and thermal therapy. However, limited research is currently found in the open literature that refers to nanosystems combining all these mentioned areas (theranostics). When developing nanosystems intended as theranostics applied to CRC, possible variations between patients must be considered. Therefore, multiple in vitro assays are required as guidance for future preclinical and clinical trials. The objective of this contribution is to evaluate the available and recent literature regarding the interactions of MNP and CRC models, aiming to critically analyze the information given by the commonly used assays and evaluate the data provided by each one with a view to implementing this novel technology in CRC diagnostics and therapy.

中文翻译：

体外生物学测试是验证大肠癌模型磁性纳米治疗的第一个工具。

大肠癌（CRC）仍然是癌症死亡的主要原因。纳米技术致力于获得更有效的治疗。在这种情况下，磁性纳米颗粒（MNP）已针对与CRC相关的广泛生物医学应用进行了研究，例如诊断成像，药物输送和热疗。但是，目前在公开文献中发现的研究有限，涉及纳米系统结合了所有上述提到的领域（热学）。在开发旨在用作CRC的诊断学的纳米系统时，必须考虑患者之间的可能差异。因此，多次体外需要进行测定以作为未来临床前和临床试验的指南。该贡献的目的是评估有关MNP和CRC模型相互作用的现有文献和最新文献，旨在严格分析常用测定法提供的信息并评估每个测定法提供的数据，以实现这一新技术在CRC诊断和治疗中。

更新日期：2020-06-23

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