Site‐Selective Trifluoromethylation Reactions of Oligopeptides,Asian Journal of Organic Chemistry

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Site‐Selective Trifluoromethylation Reactions of Oligopeptides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-05-04 , DOI: 10.1002/ajoc.202000170
Itziar Guerrero ₁ , Arkaitz Correa ₁

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Site‐selective chemical modifications that target proteinogenic amino acid residues complement the methods entailing genetic manipulation, thereby allowing straightforward and rapid access to engineered proteins. The incorporation of the trifluoromethyl group into amino acids within a peptide sequence results in relevant peptidomimetics with unique biomedicinal properties. As a result, the last decade has witnessed the development of a powerful set of protocols toward the selective trifluoromethylation of small‐to‐medium size peptides and proteins in a late‐stage fashion. This minireview seeks to highlight those particularly compelling cases published in the last years.

中文翻译：

寡肽的定点三氟甲基化反应

针对蛋白原氨基酸残基的定点化学修饰可补充需要遗传操作的方法，从而可以直接，快速地获得工程蛋白。将三氟甲基基团掺入肽序列内的氨基酸中可得到具有独特生物医学特性的相关拟肽。结果，在过去的十年中，目睹了一系列功能强大的协议的发展，这些协议以后期方式对中小型肽和蛋白质进行选择性三氟甲基化。这份小型审查旨在强调过去几年中那些特别引人注目的案例。

更新日期：2020-05-04

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