Papaya (Carica papaya Linn.) belongs to the family Caricaceae and is well known for its therapeutic and nutritional properties all over the world. The different parts of the papaya plant have been used since ancient times for its therapeutic applications. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic and antiviral activities of papaya leaf. All information presented in this review article regarding the therapeutic application of Carica papaya leaf extract has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science, and PubMed. The keywords Carica papaya, anticancer, anti-inflammatory, immunomodulatory, and phytochemicals were explored until December 2019. The papaya plant, including fruit, leaf, seed, bark, latex, and their ingredients play a major role in the management of disease progression. Carica papaya leaf contains active components such as alkaloids, glycosides, tannins, saponins, and flavonoids, which are responsible for its medicinal activity. Additionally, the leaf juice of papaya increases the platelet counts in people suffering from dengue fever. The major findings revealed that papaya leaf extract has strong medicinal properties such as antibacterial, antiviral, antitumor, hypoglycaemic and anti-inflammatory activity. Furthermore, clinical trials are needed to explore the medicative potential of papaya leaf. Graphical abstract Graphical abstract showing the medicinal properties of Carica papaya leaf Graphical abstract showing the medicinal properties of Carica papaya leaf

中文翻译：

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番木瓜叶提取物在人类疾病管理中的治疗应用

木瓜（Carica papaya Linn.）属于木瓜科，以其治疗和营养特性而闻名于世。木瓜植物的不同部分自古以来就被用于治疗用途。在此，我们旨在综述木瓜叶的抗癌、抗炎、抗糖尿病和抗病毒活性。这篇综述文章中提供的有关番木瓜叶提取物治疗应用的所有信息都是通过访问各种电子数据库获得的，包括 Scopus、谷歌学者、Web of science 和 PubMed。截至 2019 年 12 月，我们对关键词番木瓜、抗癌、抗炎、免疫调节和植物化学物质进行了探索。番木瓜植物，包括果实、叶子、种子、树皮、乳胶及其成分在疾病进展的控制中发挥着重要作用。番木瓜叶含有生物碱、糖苷、单宁、皂苷和黄酮类等活性成分，这些活性成分决定了其药用活性。此外，木瓜叶汁可以增加登革热患者的血小板计数。主要研究结果表明，木瓜叶提取物具有很强的药用特性，如抗菌、抗病毒、抗肿瘤、降血糖和抗炎活性。此外，还需要进行临床试验来探索木瓜叶的药用潜力。图解摘要 显示番木瓜叶药用特性的图解摘要 显示番木瓜叶药用特性的图解摘要