We thank Cure et al¹ for their comments about our paper entitled “Association of serum osmolarity with contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction.”² They stated that the usage of directly measured serum osmolality instead of calculated serum osmolarity may have affected the study results. However, directly measured serum osmolality would add cost in laboratory time, resource, and expense but calculated serum osmolarity would add no additional cost in routine practice. The osmolar gap is determined by subtracting the calculated serum osmolarity from the measured serum osmolality.³ Due to the retrospective design of our study, it would be impossible to exclude all the factors that may have affected osmolar gap and this was not the scope of our study. Whether the results of the study will change in case the factors that may affect osmolar gap are excluded from the study is the subject of another prospective study.

中文翻译：

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对题为“'ST段抬高型心肌梗死患者的血清渗透压与造影剂诱发的肾病的关系'的评论”的回复。

我们感谢Cure等人¹对他们的论文发表的评论，即“ ST段抬高型心肌梗死患者的血清渗透压与对比剂诱发的肾病（CIN）的关联”。²他们指出使用直接测量的血清渗透压代替计算的血清渗透压可能会影响研究结果。但是，直接测量的血清渗透压会增加实验室时间，资源和费用的成本，但是计算得出的血清渗透压在常规实践中不会增加任何成本。通过从测得的血清渗透压减去计算的血清渗透压来确定渗透压间隙。³由于我们研究的回顾性设计，不可能排除所有可能影响渗透压间隙的因素，这不是我们研究的范围。如果将可能影响渗透压间隙的因素排除在研究之外，则研究结果是否会改变是另一项前瞻性研究的主题。