The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.

中文翻译：

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COVID-19 / ACE2对女性生殖系统的潜在影响。

2019年新颖的冠状病毒（2019-nCoV）于2019年12月出现，然后迅速在全球传播。该病毒通过与血管紧张素转化酶（ACE）2结合而侵入靶细胞，并调节宿主细胞中ACE2的表达。ACE2是肾素-血管紧张素系统的关键组成部分，它通过调节血管紧张素II（Ang II）和Ang-（1-7）的水平发挥其生理功能。我们回顾了报道ACE2在女性生殖系统中的分布和功能的文献，以期阐明2019-nCoV对女性生育力的潜在危害。现有证据表明，ACE2在卵巢，子宫，阴道和胎盘中广泛表达。因此，我们认为，除了飞沫和接触传播外，还存在母婴传播和性传播的可能性。Ang II，ACE2和Ang-（1-7）调节卵泡发育和排卵，调节黄体血管生成和变性，还影响子宫内膜组织和胚胎发育的规律性变化。考虑到这些功能，2019-nCoV可能会通过调节ACE2干扰女性生殖功能。