p53 and γ-synuclein are two major regulators of cancer pathogenesis that have the propensity to form amyloid-like fibrils reminiscent of those in neurodegenerative diseases. Here we propose that fibril formation by these amyloidogenic molecules reflects evolvability, an acquired epigenetic inheritance that may be involved in cancer proliferation, drug resistance, and metastasis.

中文翻译：

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淀粉样蛋白可进化性和癌症。

p53 和 γ-突触核蛋白是癌症发病机制的两个主要调节因子，它们倾向于形成类似神经退行性疾病的淀粉样纤维。在这里，我们提出这些淀粉样蛋白分子形成的原纤维反映了可进化性，这是一种可能与癌症增殖、耐药性和转移有关的获得性表观遗传。