The repertoire of dendritic cells (DCs), monocytes and macrophages in adult humans is diverse and we are appreciating this to a greater extent as high throughput methods, such a single-cell RNA sequencing, become widely adopted and scalable. This powerful lens of analysis is also beginning to shed light on prenatal immunology, allowing us to chart the emergence, tissue distribution and developmental regulation of DCs, monocytes and macrophages during early human life. In this review, we will integrate recent insights from studies of the developing immune system into our understanding of adult DC, monocyte and macrophage organization, illustrating where insights from early life both affirm and challenge current understanding.

中文翻译：

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使用单细胞技术重建子宫内的人类DC，单核细胞和巨噬细胞发育。

成年树突状细胞（DC），单核细胞和巨噬细胞的组成是多种多样的，并且随着高通量方法（例如单细胞RNA测序）被广泛采用和可扩展，我们对此表示更大的赞赏。这种强大的分析手段也开始阐明产前免疫学，使我们能够绘制出人类早期生命中DC，单核细胞和巨噬细胞的出现，组织分布和发育规律。在这篇综述中，我们将把对免疫系统发育的研究的最新见识整合到对成人DC，单核细胞和巨噬细胞组织的理解中，从而说明早年的见识在哪里肯定并挑战了当前的理解。