The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.

这项工作的目的是研究微晶纤维素（MCC）的制造条件，其理化性质和其压片行为之间的关系。使用两种不同的制备程序，通过酸水解法从小麦秸秆生产MCC，或者仅使用硫酸，或者使用硫酸和盐酸的组合。使用动态粉末压实分析仪研究了获得的MCC样品以及MCC与布洛芬的混合物的压片行为。观察到，一些获得的MCC样品显示出比市售Vivapur®PH101更好的流动性，并且拉伸强度，固含量和弹性回复率也非常高。这可以与其良好的压实性能联系在一起，但另一方面，它会导致片剂崩解的问题。在与布洛芬的混合物中，MCC样品显示出较低的拉伸强度值，而另一方面，弹性回复似乎并未受到太大影响，仍显示出非常高的值。根据所得结果，可以得出结论，从农业废弃物中获得的MCC对于通过直接压片法制备片剂具有令人满意的性能。为了获得更好的理化特性，尤其是在弹性回复方面，需要进一步研究以优化工艺条件。根据所得结果，可以得出结论，从农业废弃物中获得的MCC对于通过直接压片法制备片剂具有令人满意的性能。为了获得更好的理化特性，尤其是在弹性回复方面，需要进一步研究以优化工艺条件。根据所得结果，可以得出结论，从农业废弃物中获得的MCC对于通过直接压片法制备片剂具有令人满意的性能。为了获得更好的理化特性，尤其是在弹性回复方面，需要进一步研究以优化工艺条件。