Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.

中文翻译：

---

产前暴露于邻苯二甲酸盐和男性生殖系统发育：来自加拿大妊娠队列研究的结果。

我们的目标是确定孕妇在足月单胎时出生时的早孕期尿中邻苯二甲酸酯浓度是否与阴茎长度（PL）或宽度（PW）减少有关。从参加加拿大妊娠队列研究（MIREC）的母亲那里获取了孕早期的邻苯二甲酸酯代谢物尿液浓度。在雄性后代出生后不久测量PL和PW。进行单变量和多变量线性回归以研究孕妇邻苯二甲酸酯暴露与阴茎测量之间的关联，并调整混杂因素。在对170对母婴进行单变量分析时，PW与邻苯二甲酸三-3-羧丙基邻苯二甲酸酯的浓度（MCPP-p = 0.016）呈反比关系，在多变量分析中并未得到证实。婴幼儿多变量分析控制 的大小和其他混杂因素，未发现邻苯二甲酸酯代谢物浓度与PL或PW之间有统计学意义的关联。在这一加拿大女性人群中，没有强有力的证据表明孕妇足月妊娠前三个月的尿中邻苯二甲酸酯与PL或PW之间存在关联。