BACKGROUND With the increasing rate of antibiotic resistance in Acinetobacter, the World Health Organization introduced the carbapenem-resistant isolates in the priority pathogens list for which innovative new treatments are urgently needed. Antimicrobial peptides (AMPs) are one of the antimicrobial agents with high potential to produce new anti-Acinetobacter drugs. This review aims to summarize recent advances and compare AMPs with anti-Acinetobacter baumannii activity. METHODS Active AMPs against Acinetobacter were considered, and essential features, including structure, mechanism of action, anti-A. baumannii potent, and other prominent characteristics, were investigated and compared to each other. In this regard, the Google Scholar search engine and databases of PubMed, Scopus, and Web of Science were used. RESULTS Forty-six anti-Acinetobacter peptides were identified and classified into ten groups: Cathelicidins, Defensins, Frog AMPs, Melittin, Cecropins, Mastoparan, Histatins, Dermcidins, Tachyplesins, and computationally designed AMPs. According to the Minimum Inhibitory Concentration (MIC) reports, six peptides of Melittin, Histatin-8, Omega76, AM-CATH36, Hymenochirin, and Mastoparan have the highest anti-A. baumannii power against sensitive and antibiotic-resistant isolates. All anti-Acinetobacter peptides except Dermcidin have a net positive charge. Most of these peptides have alpha-helical structure; however, β-sheet and other structures have been observed among them. The mechanism of action of these antimicrobial agents is divided into two categories of membrane-based and intracellular target-based attack. CONCLUSION Evidence from this review indicates that AMPs would be likely among the main anti-A. baumannii drugs in the post-antibiotic era. Also, the application of computer science to increase anti-A. baumannii activity and reduce toxicity could be helpful.

中文翻译：

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抗菌肽是针对鲍曼不动杆菌感染的有前途的治疗选择。

背景技术随着不动杆菌中抗生素耐药性的增加，世界卫生组织在优先病原体清单中引入了对碳青霉烯类耐药菌的分离，迫切需要创新的新疗法。抗菌肽（AMPs）是具有产生新抗不动杆菌药物的高潜力的抗菌剂之一。这篇综述旨在总结最近的进展，并将AMP与抗鲍曼不动杆菌的活性进行比较。方法考虑抗不动杆菌的活性AMP，并考虑其基本特征，包括结构，作用机理，抗A。对鲍曼曼氏菌强效和其他突出特征进行了研究并进行了比较。在这方面，使用了Google Scholar搜索引擎以及PubMed，Scopus和Web of Science的数据库。结果确定了46种抗不动杆菌肽并将其分为十类：速激肽，防御素，青蛙AMP，melittin，天蚕素，马斯妥安，Histatins，Dermcidins，Tachyplesins和通过计算设计的AMP。根据最小抑菌浓度（MIC）报告，Melittin，Histatin-8，Omega76，AM-CATH36，Hymenochirin和Mastoparan的六种肽具有最高的抗A素。鲍曼氏菌具有抗敏感和抗药性菌株的能力。除真皮蛋白外的所有抗不动杆菌肽均带有净正电荷。这些肽大多数具有α-螺旋结构。然而，其中已经观察到β-折叠和其他结构。这些抗微生物剂的作用机理分为基于膜的攻击和基于细胞内靶标的攻击的两类。结论这篇综述的证据表明AMPs可能是主要的抗A药之一。后抗生素时代的鲍曼氏药物。另外，计算机科学的应用增加了抗A。鲍曼活性和降低毒性可能会有所帮助。