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Fumonisin-(Fusarium verticillioides)-contaminated feed causes hepatic oxidative stress and negatively affects broiler performance in the early stage: Does supplementation with açai flour residues (Euterpe oleracea) minimize these problems?
Microbial Pathogenesis ( IF 3.3 ) Pub Date : 2020-05-05 , DOI: 10.1016/j.micpath.2020.104237
Marcela C S Sousa 1 , Gabriela M Galli 1 , Nathieli B Bottari 2 , Davi F Alba 1 , Karoline W Leal 1 , Thalison F Lopes 2 , Letícia Druzian 2 , Maria Rosa C Schetinger 2 , Eduardo M Gloria 3 , Ricardo E Mendes 4 , Lenita M Stefani 1 , Aleksandro S Da Silva 5
Affiliation  

Fusarium verticillioides is often responsible for contamination of poultry feed with the mycotoxin fumonisin. The aim of this study was to determine whether oxidative stress caused by intake of fumonisin-contaminated feed affects broiler performance at an early stage of development, as well as to test whether the addition of açai residue flour to contaminated feed would minimize these negative effects of redox metabolism. Birds were divided into four groups, with four repetitions of five animals each: control (TC) - birds that received basal feed; TCA treatment - basal feed supplemented with 2% açai flour; TF treatment - feed experimentally contaminated with fumonisin (10 ppm); TFA treatment - fumonisin-contaminated feed (10 ppm) and supplemented with açai fluor (2%). The experiment lasted 20 days, that is, the first 20 days of the chicks' lives. At the end of the experiment, the birds were weighed, and blood, intestine and liver samples were collected. The TCA and TFA had greater body weights and weight gain than did TF. Further, TCA and TFA had lower feed conversion than did TF. Açai flour intake (TCA and TFA) stimulated albumin synthesis and reduced serum AST activity. Nitrate/nitrite (NOx) levels were higher in serum of fumonisin-challenged (TF) birds than in groups; NOx levels were also higher in the livers of all test groups (TF, TCA and TFA) than in TC. Serum glutathione S-transferase (GST) activity was lower in fumonisin-consuming groups (TF and TFA); this was different from what occurred in the liver, that is, higher GST activity in TF and lower activity in TFA than in TC. Catalase activity (CAT) was also higher in the fumonisin-challenged groups (TF and TFA) and the groups supplemented with açai flour (TCA) than in TC. Serum reactive species (RS) and TBARS (lipid peroxidation) levels in the liver were lower in birds supplemented with açai flour and exposed to fumonisin. These data suggest that the addition of açai flour in the feed of early chickens improves animal performance and minimizes the effects of hepatic oxidative stress in birds fed fumonisin-contaminated feed.

中文翻译:

受伏马菌素-(Fusarium v​​erticillioides)污染的饲料会在早期阶段引起肝氧化应激并对肉鸡的生产性能产生负面影响:补充阿萨伊面粉残留物(Euterpe oleracea)是否可以最大程度地减少这些问题?

镰刀菌镰刀菌经常造成霉菌毒素伏马菌素污染家禽饲料。这项研究的目的是确定因食用伏马毒素而被污染的饲料的摄入所引起的氧化应激是否会在发展的早期阶段影响肉鸡的生产,并检验向受污染的饲料中添加阿萨伊渣粉是否能最大程度地减少这些饲料的负面影响。氧化还原代谢。鸟类分为四组,每组五只动物四次重复:对照(TC)-接受基础饲料的鸟类;TCA处理-补充2%阿萨伊粉的基础饲料;TF处理-实验中被伏马菌素(10 ppm)污染的饲料;TFA处理-受到伏马菌素污染的饲料(10 ppm),并补充氟利昂(2%)。实验持续了20天,即小鸡的前20天 生活。实验结束时,称量鸡的体重,并收集血液,肠和肝样本。TCA和TFA比TF具有更大的体重和体重增加。此外,TCA和TFA的进料转化率低于TF。摄入阿萨伊粉(TCA和TFA)可刺激白蛋白合成并降低血清AST活性。伏马菌素攻击(TF)鸟的血清中硝酸盐/亚硝酸盐(NOx)水平高于各组;在所有测试组(TF,TCA和TFA)的肝脏中,NOx水平也均高于TC。服用伏马毒素的组(TF和TFA)的血清谷胱甘肽S-转移酶(GST)活性较低。这与肝脏中发生的情况不同,即TF中的GST活性较高,而TFA中的活性低于TC。富马菌素攻击组(TF和TFA)和补充阿萨伊粉(TCA)的组中的过氧化氢酶活性(CAT)也高于TC。补充了阿萨伊粉并暴露于伏马毒素的家禽中,肝脏的血清反应性物种(RS)和TBARS(脂质过氧化)水平较低。这些数据表明,在早鸡的饲料中添加阿萨伊粉可改善动物的生产性能,并最大程度地减少饲喂伏马菌素污染的饲料对家禽的肝脏氧化应激的影响。
更新日期:2020-05-05
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