Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlations indicate β cell compensation in type 2 diabetes.

中文翻译：

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从转录组到电生理学：寻找糖尿病的根本原因。

朗格汉斯岛内的细胞是异质的。Camunas-Soler 等人。(2020) 实施 patch-seq 技术从同一细胞收集转录组学和电生理学数据。通过这样做，他们发现了与功能异质性相关的新基因，并发现这些相关性的变化表明 2 型糖尿病中的 β 细胞代偿。