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Molecular shape as a key source of prebiotic information.
Journal of Theoretical Biology ( IF 1.9 ) Pub Date : 2020-05-05 , DOI: 10.1016/j.jtbi.2020.110316
Hugo I Cruz-Rosas 1 , Francisco Riquelme 2 , Alejandra Ramírez-Padrón 1 , Thomas Buhse 3 , Germinal Cocho 4 , Pedro Miramontes 1
Affiliation  

One of the most striking features of a living system is the self-sustaining functional inner organization, which is only possible when a source of internal references is available from which the system is able to self-organize components and processes. Internal references are intrinsically related to biological information, which is typically understood as genetic information. However, the organization in living systems supports a diversity of intricate processes that enable life to endure, adapt and reproduce because of this organization. In a biological context, information refers to a complex relationship between internal architecture and system functionality. Nongenetic processes, such as conformational recognition, are not considered biological information, although they exert important control over cell processes. In this contribution, we discuss the informational nature in the recognition of molecular shape in living systems. Thus, we highlight supramolecular matching as having a theoretical key role in the origin of life. Based on recent data, we demonstrate that the transfer of molecular conformation is a very likely dynamic of prebiotic information, which is closely related to the origin of biological homochirality and biogenic systems. In light of the current hypothesis, we also revisit the central dogma of molecular biology to assess the consistency of the proposal presented here. We conclude that both spatial (molecular shape) and sequential (genetic) information must be represented in this biological paradigm.

中文翻译:

分子形状是益生元信息的关键来源。

生命系统最显着的特征之一是自我维持的功能内部组织,只有当系统能够自我组织组件和过程的内部参考来源可用时,这才有可能。内部引用本质上与生物信息相关,生物信息通常被理解为遗传信息。然而,生命系统中的组织支持各种复杂的过程,这些过程使生命能够因为这个组织而得以生存、适应和繁殖。在生物学背景下,信息是指内部架构和系统功能之间的复杂关系。非遗传过程,例如构象识别,不被视为生物信息,尽管它们对细胞过程发挥重要控制作用。在本次投稿中,我们讨论了识别生命系统中分子形状的信息性质。因此,我们强调超分子匹配在生命起源中具有理论上的关键作用。基于最近的数据,我们证明了分子构象的转移很可能是益生元信息的动态变化,这与生物同手性和生物系统的起源密切相关。根据当前的假设,我们还重新审视了分子生物学的中心法则,以评估此处提出的建议的一致性。我们得出结论,空间(分子形状)和顺序(遗传)信息都必须在这种生物学范式中表示。我们强调超分子匹配在生命起源中具有理论上的关键作用。基于最近的数据,我们证明了分子构象的转移很可能是益生元信息的动态变化,这与生物同手性和生物系统的起源密切相关。根据当前的假设,我们还重新审视了分子生物学的中心法则,以评估此处提出的建议的一致性。我们得出结论,空间(分子形状)和顺序(遗传)信息都必须在这种生物学范式中表示。我们强调超分子匹配在生命起源中具有理论上的关键作用。基于最近的数据,我们证明了分子构象的转移很可能是益生元信息的动态变化,这与生物同手性和生物系统的起源密切相关。根据当前的假设,我们还重新审视了分子生物学的中心法则,以评估此处提出的建议的一致性。我们得出结论,空间(分子形状)和顺序(遗传)信息都必须在这种生物学范式中表示。根据当前的假设,我们还重新审视了分子生物学的中心法则,以评估此处提出的建议的一致性。我们得出结论,空间(分子形状)和顺序(遗传)信息都必须在这种生物学范式中表示。根据当前的假设,我们还重新审视了分子生物学的中心法则,以评估此处提出的建议的一致性。我们得出结论,空间(分子形状)和顺序(遗传)信息都必须在这种生物学范式中表示。
更新日期:2020-05-05
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