SummaryPolyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. This paper describes for the first time an octaploid embryo implanted in mice despite hyper-polyploidization, and indicates that these mammalian embryos have the ability to implant, and even develop, despite the harmfulness of extreme whole genome duplication.

中文翻译：

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超多倍体胚胎在植入小鼠后存活

摘要自然全基因组复制产生的多倍体已成为脊椎动物进化的动力。作为进化的证据，多倍体生物普遍存在，但是没有关于哺乳动物中多倍体生物的报道。在小鼠中，正常培养条件下的多倍体胚胎通常发育到囊胚期。然而，大多数四倍体胚胎在植入后退化，表明全基因组复制对小鼠的正常发育产生有害影响。大多数先前关于多倍体的研究主要集中在四倍体胚胎上。分析各种倍性结果对于理解多倍化对胚胎发育的影响很重要。本研究的目的是发现多倍体化对植入后胚胎植入和发育的影响程度。本文首次描述了在超多倍体化的情况下植入小鼠体内的八倍体胚胎，并指出这些哺乳动物胚胎具有植入甚至发育的能力，尽管极端的全基因组重复是有害的。